The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
University of Namibia
Abstract
A known compound namely 1E,3R,4S,5E,7Z-1-bromo-3,4,8-trichloro-7-
(dichloromethyl)-3-methylocta-1,5,7-triene was isolated from a Namibian Plocamium
species for the first time and characterized by means of one and two dimensional
Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectrometry
(MS) analysis. The compound exhibited minimal inhibition against HIV-1 reverse
transcriptase, with a 50% inhibitory concentration of > 1000μM. However, literature
reviews indicate that this compound has good cytotoxic in vitro effects.
Description
Keywords
Halogenated monoterpenes, Plocamium, Cytotoxic
Citation
Knott, M.G., Kapewangolo, P., Louw, S., Kandjengo, L., & Ishola, A. (2016). The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species. International Science and Technology Journal of Namibia, 7, 59-72.