The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species select="/dri:document/dri:meta/dri:pageMeta/dri:metadata[@element='title']/node()"/>

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dc.contributor.author Knott, Michael G.
dc.contributor.author Kapewangolo, Petrina T.
dc.contributor.author Louw, Stefan
dc.contributor.author Brand, J
dc.contributor.author Kandjengo, Lineekela
dc.contributor.author Ishola, Anthony
dc.date.accessioned 2016-06-10T14:40:46Z
dc.date.available 2016-06-10T14:40:46Z
dc.date.issued 2016
dc.identifier.citation Knott, M.G., Kapewangolo, P., Louw, S., Kandjengo, L., & Ishola, A. (2016). The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species. International Science and Technology Journal of Namibia, 7, 59-72. en_US
dc.identifier.issn 2026-7673
dc.identifier.uri http://hdl.handle.net/11070/1756
dc.description.abstract A known compound namely 1E,3R,4S,5E,7Z-1-bromo-3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene was isolated from a Namibian Plocamium species for the first time and characterized by means of one and two dimensional Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectrometry (MS) analysis. The compound exhibited minimal inhibition against HIV-1 reverse transcriptase, with a 50% inhibitory concentration of > 1000μM. However, literature reviews indicate that this compound has good cytotoxic in vitro effects. en_US
dc.language.iso en en_US
dc.publisher University of Namibia en_US
dc.subject Halogenated monoterpenes en_US
dc.subject Plocamium en_US
dc.subject Cytotoxic en_US
dc.title The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species en_US
dc.type Article en_US


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