Using parasite genetic and human mobility data to infer local and cross-border Malaria connectivity in Southern Africa

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dc.contributor.authorTessema, Sofonias
dc.contributor.authorWesolowski, Amy
dc.contributor.authorMumbengegwi, Davis R.
dc.date.accessioned2020-02-24T09:05:36Z
dc.date.available2020-02-24T09:05:36Z
dc.date.issued2019
dc.description.abstractLocal and cross-border importation remain major challenges to malaria elimination and are difficult to measure using traditional surveillance data. To address this challenge, we systematically collected parasite genetic data and travel history from thousands of malaria cases across northeastern Namibia and estimated human mobility from mobile phone data. We observed strong fine-scale spatial structure in local parasite populations, providing positive evidence that the majority of cases were due to local transmission. This result was largely consistent with estimates from mobile phone and travel history data. However, genetic data identified more detailed and extensive evidence of parasite connectivity over hundreds of kilometers than the other data, within Namibia and across the Angolan and Zambian borders. Our results provide a framework for incorporating genetic data into malaria surveillance and provide evidence that both strengthening of local interventions and regional coordination are likely necessary to eliminate malaria in this region of Southern Africa.en_US
dc.identifier.citationTessema, S., et al. (2019). Using parasite genetic and human mobility data to infer local and cross- border malaria connectivity in Southern Africa. eLife, 8, 1-20.en_US
dc.identifier.urihttp://hdl.handle.net/11070/2688
dc.language.isoenen_US
dc.subjectMaxwell Murphyen_US
dc.subjectJordan Wilheimen_US
dc.subjectAnna-Rosa Mupirien_US
dc.subjectNick W Ruktanonchaien_US
dc.subjectVictor A Aleganaen_US
dc.subjectAndrew J Tatemen_US
dc.subjectMunyaradzi Tamboen_US
dc.subjectBradley Didieren_US
dc.subjectJustin M Cohenen_US
dc.subjectAdam Bennetten_US
dc.subjectHugh JW Sturrocken_US
dc.subjectRoland Goslingen_US
dc.subjectMichelle S Hsiangen_US
dc.subjectDavid L Smithen_US
dc.subjectJennifer L Smithen_US
dc.subjectBryan Greenhouseen_US
dc.titleUsing parasite genetic and human mobility data to infer local and cross-border Malaria connectivity in Southern Africaen_US
dc.typeArticleen_US
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