Shilunga, A.Mutangara, A.M.2026-06-172026-06-172025http://hdl.handle.net/11070/4252A research mini-thesis submitted in partial-fulfilment of the requirement for the degree of Master of Public HealthAdequate knowledge, attitude, and practice of HIV Pre-Exposure Prophylaxis (PrEP) are crucial for HIV prevention, especially in regions with high infection rates. Despite its life-saving potential, there remains a glaring gap in school based PrEP education in Namibia, leaving adolescents under-informed and vulnerable. This study aimed to assess knowledge, attitude, and practice regarding HIV PrEP among adolescents in secondary schools in Grootfontein district, Otjozondjupa region, Namibia. Methodology: The study used a quantitative, cross-sectional design, 341 learners were sampled from three secondary schools. Non-probability judgmental sampling selected the schools, followed by stratified random sampling to select the learner’s respondents. Results: The findings showed that most respondents were females (62.2%), aged 15-19 years (79.5%). About 54.5% had never heard of HIV PrEP, and only 15.2% knew that PrEP is specifically for HIV-negative individuals. While 49.5% recognized PrEP as an antiretroviral treatment for HIV Prevention, 39.9% were unsure. A majority (39.3%) understood PrEP’s use when at risk of HIV, and 45.2% would feel comfortable discussing PrEP with healthcare providers. Additionally, 42.8% indicated they would recommend PrEP to a friend or partner, with 51.6% agreeing it is essential for adolescents to have access to PrEP. Conclusion: The study found significant links between demographic factors and HIV PrEP-related knowledge, attitudes, and practices. Despite positive attitudes, gaps in knowledge and practice persist, underscoring the need for targeted, school-based sexual education interventionsenAdolescentsKnowledgeAttitudesExposureProphylaxisHuman Immunodeficiency VirusesNamibiaUniversity of NamibiaThesis