Seroprevalence of African horse sickness in selected donkey populations in Namibia

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dc.contributor.authorMolini, Umberto
dc.contributor.authorZaccaria, Guendalina
dc.contributor.authorKandiwa, Erick
dc.contributor.authorMushonga, Borden
dc.contributor.authorKhaiseb, S.
dc.contributor.authorNtahonshikira, Charles
dc.contributor.authorChiwome, Bernard
dc.contributor.authorBaines, Ian John
dc.contributor.authorMadzingira, Oscar
dc.contributor.authorSavini, Giovanni
dc.contributor.authorD’Alterio, Nicola
dc.date.accessioned2020-06-09T05:28:14Z
dc.date.available2020-06-09T05:28:14Z
dc.date.issued2020
dc.description.abstractBackground and Aim: African horse sickness (AHS) is a non-contagious viral disease of horses and other equids caused by an arbovirus belonging to the Reoviridae family and genus Orbivirus. AHS is an endemic disease that is responsible for the death of a high number of horses every year in Namibia. At present, there is no information on the prevalence and distribution of AHS virus (AHSV) serotypes in the different regions of Namibia. Therefore, this survey aimed to fill this knowledge gap by investigating the AHSV seroprevalence in Namibian donkeys. Materials and Methods: A total of 260 blood samples (20 samples for each region) were randomly collected from donkeys aged between 3 and 5 years. Sera were screened for AHSV-specific immunoglobulin G antibodies using a commercial competitive enzyme-linked immunosorbent assay kit and samples positive to AHSV antibodies were further tested by serum neutralization (SN) assay to evaluate the AHSV serotype-specific immune response. Results: Seroprevalence of antibodies against AHSV in Namibian donkeys was 63.5%. The AHSV prevalence was significantly higher in the northern region (64%) than in the southern region (36%). A significantly (p<0.05) higher number of donkeys had antibodies against AHSV-6 (37.8%) and AHSV-9 (37.8%). The AHSV-2, AHSV-6, and AHSV-9 prevalence were higher (p<0.05) in the northern regions compared to the southern regions. None of the donkeys in this study, however, tested positive for AHSV-8. Conclusion: Results of the current study indicate that all AHSV serotypes have either circulated previously or are circulating in Namibia except for AHSV-8. In particular, AHSV-1, -2, -3, -4, -5, -6, and -9 serotypes have circulated or are circulating in the northern region of Namibia, while AHSV-1, -4, -5, -6, -7, and -9 have infected donkeys in the south. AHSV-9 and AHSV-6 were the most prevalent serotypes detected in donkeys in this study. SN results showed that several donkeys from Kavango East, Kavango West, and Ohangwena regions had been exposed to multiple serotypes, indicating the possibility of cocirculation of several strains in Namibia.en_US
dc.identifier.citationMolini, U., et al. (2020). Seroprevalence of African horse sickness in selected donkey populations in Namibia. Veterinary World, 13(5), 1005-1009.en_US
dc.identifier.urihttp://hdl.handle.net/11070/2750
dc.language.isoenen_US
dc.publisherUniversity of Namibiaen_US
dc.subjectAfrican horse sicknessen_US
dc.subjectDonkeysen_US
dc.titleSeroprevalence of African horse sickness in selected donkey populations in Namibiaen_US
dc.typeArticleen_US
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