The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species
| dc.contributor.author | Knott, Michael G. | |
| dc.contributor.author | Kapewangolo, Petrina T. | |
| dc.contributor.author | Louw, Stefan | |
| dc.contributor.author | Brand, J. | |
| dc.contributor.author | Kandjengo, Lineekela | |
| dc.contributor.author | Ishola, Anthony | |
| dc.date.accessioned | 2016-06-10T14:40:46Z | |
| dc.date.available | 2016-06-10T14:40:46Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | A known compound namely 1E,3R,4S,5E,7Z-1-bromo-3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene was isolated from a Namibian Plocamium species for the first time and characterized by means of one and two dimensional Nuclear Magnetic Resonance (NMR) spectroscopic data and Mass Spectrometry (MS) analysis. The compound exhibited minimal inhibition against HIV-1 reverse transcriptase, with a 50% inhibitory concentration of > 1000μM. However, literature reviews indicate that this compound has good cytotoxic in vitro effects. | en_US |
| dc.identifier.citation | Knott, M.G., Kapewangolo, P., Louw, S., Kandjengo, L., & Ishola, A. (2016). The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species. International Science and Technology Journal of Namibia, 7, 59-72. | en_US |
| dc.identifier.issn | 2026-7673 | |
| dc.identifier.uri | http://hdl.handle.net/11070/1756 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of Namibia | en_US |
| dc.subject | Halogenated monoterpenes | en_US |
| dc.subject | Plocamium | en_US |
| dc.subject | Cytotoxic | en_US |
| dc.title | The isolation, structural determination and bioactivity of 1E,3R,4S,5E,7Z-1-bromo 3,4,8-trichloro-7- (dichloromethyl)-3-methylocta-1,5,7-triene from a Namibian Plocamium species | en_US |
| dc.type | Article | en_US |